TY  - EJOUR
AU  - Lee, Geonho 
AU  - Park, Jongwook 
AU  - Jang, Seong H. 
AU  - Lee, Sang Y. 
AU  - Seong, Jihyun 
AU  - Jung, Jae W. 
AU  - Kim, Kyobum 
AU  - Hwang, Tae G. 
AU  - Choi, Jun 
TI  - Synthesis and Characterization of Diketopyrrolopyrrole-Based Aggregation-Induced Emission Nanoparticles for Bioimaging
T2  - Molecules
PY  - 2022
VL  - 27
IS  - 9
SN  - 1420-3049
AB  - Conventional fluorescent dyes have the property of decreasing fluorescence due to aggregation-caused quenching effects at high concentrations, whereas aggregation-induced emission dyes have the property of increasing fluorescence as they aggregate with each other. In this study, diketopyrrolopyrrole-based long-wavelength aggregation-induced emission dyes were used to prepare biocompatible nanoparticles suitable for bioimaging. Aggregation-induced emission nanoparticles with the best morphology and photoluminescence intensity were obtained through a fast, simple preparation method using an ultrasonicator. The optimally prepared nanoparticles from 3,6-bis(4-((E)-4-(bis(40-(1,2,2-triphenylvinyl)-[1,10-biphenyl]-4-yl)amino)styryl)phenyl)-2,5-dihexyl-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (DP-R2) with two functional groups having aggregation-induced emission properties and additional donating groups at the end of the triphenylamine groups were considered to have the greatest potential as a fluorescent probe for bioimaging. Furthermore, it was found that the tendency for aggregation-induced emission, which was apparent for the dye itself, became much more marked after the dyes were incorporated within nanoparticles. While the photoluminescence intensities of the dyes were observed to decrease rapidly over time, the prepared nanoparticles encapsulated within the biocompatible polymers maintained their initial optical properties very well. Lastly, when the cell viability test was conducted, excellent biocompatibility was demonstrated for each of the prepared nanoparticles.
KW  - dyes
KW  - aggregation-induced emission
KW  - nanoparticles
KW  - fluorescence
KW  - dispersibility
KW  - bioimaging
DO  - 10.3390/molecules27092984
ER  -